A preparative chiral separation of hydroxychloroquine using supercritical fluid chromatography
نویسندگان
چکیده
منابع مشابه
Preparative Supercritical Fluid Chromatography
Supercritical Suid chromatography (SFC) on a preparative scale is of interest because of its advantages over high performance liquid chromatography (HPLC). The high diffusivity and low viscosity of supercritical Suids allow rapid separation. The solvent strength can easily be controlled by changing pressure and/or temperature, so that mobile phases with a Rxed composition can be used to separat...
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Hexabromocyclododecane (HBCDD) is an additive brominated flame retardant which has been listed in Annex A of the Stockholm Convention for elimination of production and use. It has been reported to persist in the environment and has the potential for enantiomer-specific degradation, accumulation, or both, making enantioselective analyses increasingly important. The six main stereoisomers of tech...
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The separation of free fatty acids was performed with supercritical fluid chromatography (SFC) on analytical lab scale apparatus. Experiments were performed using fatty acids, which occur in vegetable oils in different amounts. Free fatty acids were analyzed without derivatization. Several stationary phases of packed columns and types of detectors were used to achieve efficient free fatty acids...
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Chemical warfare nerve agents (CWNAs) are extremely toxic organophosphorus compounds that contain a chiral phosphorus center. Undirected synthesis of G-type CWNAs produces stereoisomers of tabun, sarin, soman, and cyclosarin (GA, GB, GD, and GF, respectively). Analytical-scale methods were developed using a supercritical fluid chromatography (SFC) system in tandem with a mass spectrometer for t...
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ژورنال
عنوان ژورنال: Journal of Chromatography A
سال: 2020
ISSN: 0021-9673
DOI: 10.1016/j.chroma.2020.461661